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An antifungal agent from the group of imidazole derivatives for external and local applications reduces the synthesis of ergosterol, which is a part of the cell membrane of the microbial wall and leads to a change in its structure and properties. In fungicidal concentrations, it interacts with mitochondrial and peroxidase enzymes, leading to an increase in the concentration of hydrogen peroxide to toxic levels, which also contributes to the destruction of fungal cells. The pills are active against pathogenic dermatophytes, pathogens of multi-colored lichen, erythrasma, gram-positive and gram-negative bacteria.
Bactrim - a combined drug, containing two active ingredients: sulfanamide drug sulfamethoxazole and derivative of diaminopyrimidine - trimethoprimum. Colibacillus life activity oppresses that leads to reduction of synthesis of thymine, riboflavinum, niacin, etc. group B vitamins in intestines. Duration of therapeutic effect makes 7 years.
Clotrimazole and betamethasone dipropionate cream for acne atopic dermatitis. J Am Acad Dermatol. 1999;35:821-833. 6. Lobo K, Bauchert HJ. Prodrugs and novel therapies in acne vulgaris: potential use the treatment of inflammatory acne. Semin Cutan Clotrimazole buy uk Med Surg. 2005;6:71-78. 7. Schmitt G, Dufour E, Huppert E. Combination therapy with ketoconazole and clodromycin for topical acne in a randomized, double-blinded, placebo- and active-controlled study. Oral Clin Exp Dermatol. 2000;20:101-106. 8. Mathern B, Sadek A, et al. Acne vulgaris: a review of the current pharmacologic and nonpharmacologic treatments for the treatment of inflammatory acne [abstract]. Presented at The 1st International Workshop on Topical Drug Therapy for Epidermatologically Based Rhabdomyolysis, Los Angeles, CA; October 23-25, 2004. 9. Sadek AJ, Rauch SL. Acne vulgaris: a review of the current pharmacologic and nonpharmacologic treatments for a chronic disease in men and women children. Oral Clin Exp Dermatol. 2004 May;18(2):105-113. doi: 10.1053/ocd-2000-1238. 10. Bajaj S, Dhamsook M. Clinical trials of oral antifungals using clindamycin or metronidazole as the active control with and without oral isotretinoin or tretinoin in patients with acne vulgaris: a meta-analysis of clinical trials. Indian J Dermatol. 2000;44:539-542. 11. Schmitt GK, Nachman BH. Efficacy and safety of clindamycin metronidazole. In: Vahlen BJ, Rauch SL, editors. Clindamycin and metronidazole. New York, NY: Oxford University Press; 2000. p. 119-130 12. Poonam A, Dhamsook M, Prabakaran P, et al. Randomized trial of clindamycin in adults with moderate-to-severe hypertrichosis. Indian J Dermatol. 1997;37:871-873. 13. Rauch SL, Zafrah BH. Antimicrobial therapy: treatment of hypertrichosis. Journal the American Academy of Dermatology. 2003;57:1527-1529. 14. Bajaj S, Dhamsook M, Huppert E. Oral clindamycin in the treatment of moderate to severe hypertrichosis, hyperkeratosis, seborrheic dermatitis, and epidermolysis bullosa: a meta-analysis. Indian J Dermatol. 2003 Feb;56(2):139-46. 15. Schmitt G, Duhall HU. Comparation studies on trichophyton mentagrophytes, sphaerocematides and brevis. Int J Dermatol 2002;36:1133-1138. 16. Wang TZ, Yu HL, Huang XA, Chang Coumadin and heart valve replacement S, Zhao XJ. Trichophyton mentagrophytes: a new class of microorganisms isolated from Chinese fermented bean products (C. chinensis) in China. Int J Food Microbiol. 2005 Apr 17;129:14-28. 17. Dhanani M, Sattar N, Hulshoff Pol M. Inhibition of oral antibiotic-induced colitis in vivo by trichophyton mentagrophytes. Indian J Dermatol 2002;45:1335-1340. 18. Jaffe E. Oral clindamycin in acne vulgaris: current therapeutic strategies. Clin Infect Dis 2001;36:1547-1551. doi: 10.1089/106503200011206. 19. Zhang HC, Liu SH. The role of trichophyton in acne vulgaris. Adv Fam Plast Interv Dis. 2003 Jul;16(2):107-115. 20. clotrimazolum gsk zamiennik Pusztai AY, Gertler KA. The role of Price of apriso gut drug store cosmetics brands microbiota and their contribution to acne vulgaris. Rev Dermatol Ven Zastr Med. 2002 Feb;14(1):29-38. 21. Bajaj S, Huppert E. An overview of topical therapy for hypermelanosis and acne vulgaris in adult patients. In: Mathern BJ, Rauch SL, editors. Topical Drug Therapy for Epidermatologically Based Rhabdomyolysis and Seborrheic Dermitis. New York, NY: Oxford University Press.
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